Research Laboratories

Equip the Hypnotize Big Daddy plasmid (or Enrage) and head down the stairs to the main Research Laboratories. A pair of Splicers is in the process of cutting their way through the sealed bay doors you couldn’t open earlier. Fortunately for you, there’s a heartsick Big Daddy milling about looking for his lost Little Sister. Use your plasmid of choice on the Big Daddy to have it take out the Splicers while you continue to the reception area and seal the doors. Pull the lever on the control panel to the right of the desk at the entrance; this will seal the lab for now.

Objective 3: Deploy the Lazarus Vector The Lazarus Vector is being circulated throughout Arcadia’s irrigation system. Once the light on the Irrigation Control Panel turns green you can deploy the Lazarus Vector to restore the plants and Arcadia’s air supply.

Growing a forest at the bottom of the ocean requires a pretty sophisticated irrigation system and it’s going to take a while for the Lazarus Vector to sufficiently circulate through the system. The next several minutes will be the longest in Jack’s short life, but you have to hold off the numerous Leadhead and Thuggish Splicers who flood the Research Laboratories in attempt to stop you.

Objective 4: Hold Off Ryan’s Forces Hold off Ryan’s forces until the misting control is ready.

The circulation process is a three-stage affair and as the Lazarus Vector makes it way through the irrigation system, more and more Splicers enter the Research Laboratories to attack. The waves of Splicers coincide with the mixing process and you can be sure that each time the in-game Goal Update occurs, another more threatening batch of Splicers is en route.

Continue to use the Hypnotize Big Daddy and Enrage plasmids to have your assailants fight one another instead of you. Use the Grenade Launcher to lay down Proximity Mines near the door to the lab and make your way over to the flooded section of the lab with the Circus of Values machine. Switch to the Shotgun and wait for the Splicers to appear. This is a great spot to mount your defense, since you can see the enemies coming and shock them in the water with Electro Bolt 2. This also allows you to quickly search the bodies for money and purchase additional items as needed.

You also may want to back into either of the small alcoves that opened where the garage-style doors were so that you force the Splicers to funnel towards the Big Daddy you have protecting you.

Atlas lets you know when the Lazarus Vector has finished circulating and is ready for deployment. When ready, head back up to Langford’s Office and use the right-hand lever on the Misting Control System to deploy the Lazarus Vector. Doing so restores the forests of Arcadia so they can continue to breathe life, literally, into Rapture.

Objective 5: Go to the Metro Station The only way out of the city now is Ryan. You need to take a bathysphere to reach him. The bathysphere Metro Station in Arcadia is accessed through the Rolling Hills.

Exit the Research Laboratories and make your way through back out to Rolling Hills. The door to the left leads to the Rapture Metro station in Arcadia. Pick up the Audio Diary on the park bench as you approach the bathysphere. Once on board, use the lever and select Fort Frolic as your next destination.