Hooked on ADAM

If you take full advantage of the Little Sisters, gathering as much ADAM as you can with them, and spending that ADAM on Plasmids, you can unlock the following seven Achievements/Trophies. Dealing with Little Sisters and maxing out your Plasmids is completely optional, but you won’t be able to unlock these bonuses without doing just that.

Icon	Title	Points	Trophy	Description
	Adopted a Little Sister	5	Bronze	Adopted a new Little Sister for the first time. You don’t really have a choice in the matter when it comes to adopting your first Little Sister. This bonus unlocks during your trip through Ryan Amusements—you need the ADAM to purchase the Incinerate! Plasmid—and the only way to get it and therefore advance the story is to defeat a Big Daddy and adopt the Little Sister he was protecting.
	Master Gatherer	30	Silver	Gathered 600 ADAM with Little Sisters. There are at total of 12 Little Sisters in the game, and each of them can be used to gather ADAM from two corpses. Gathers yield 40 ADAM each. Suffice to say, you must perform at least 15 Gathers to unlock this bonus. Consider performing every available Gather possible as they become available (note that you can still harvest a Little Sister after performing the Gather) to get this bonus sooner rather than later. This gives you chance to bail on Gathers during the later stages of the game, when it becomes dramatically more difficult to protect the Little Sister. If you perform every Gather presented to you, you can unlock this bonus after your third Gather in Dionysus Park. Or, you can open this Achievement/Trophy even earlier by equipping the Proud Parent Tonic.
	Dealt with Every Little Sister	50	gold	Dealt with every Little Sister. There are a total of 12 Little Sisters in BioShock 2, including the one that you must deal with as you progress through Ryan Amusements. It doesn’t matter whether you harvest or rescue the Little Sisters, only that you defeat their Big Daddy then deal with them one way or the other. Since there is no way to revisit previous locations as you progress from area to area, the number of Little Sisters you forget to deal with in one area become added to the total of Little Sisters available in the next area. For example, there are normally three Little Sisters at Siren Alley and three at Dionysus Park, but if you skip one of the Little Sisters at Siren Alley, there will be four at Dionysus Park for you to deal with. That said, there are no Little Sisters beyond Fontaine Futuristics, so you must deal with every Little Sister available before leaving this area if you wish to unlock this bonus. The following list details the default number of Little Sisters at each area.

Icon	Title	Points	Trophy	Description
	Bought a Slot	5	Bronze	Bought one Plasmid or Tonic Slot at a Gatherer’s Garden. Plasmid and Tonic Slots cost 40 and 25 ADAM, respectively, and though you begin with more than you can initially use, you’re going to need to purchase additional slots. You probably should buy your first additional slot while in Pauper’s Drop if playing as a Harvester, otherwise you may not have extra ADAM to spare until visiting Siren Alley. Note that the price of Tonic Slots does increase periodically to 35 ADAM after purchasing five, then to 45 ADAM after purchasing a total of nine.
	Max Plasmid Slots	10	Bronze	Fully upgraded to the maximum number of Plasmid Slots. There are a total of eight possible Plasmid Slots available to the player (one for each of the primary and diagonal directions on the Plasmid Radial). Players begin with just three Plasmid Slots and must buy four from the Gatherer’s Garden vending machines for 40, 50, 60, and 70 ADAM each. It’s easier to part with this extra 220 ADAM when playing as a Harvester, but even those who spend their time rescuing Little Sisters can still acquire all of the Plasmid Slots (and have ADAM to spend upgrading the most useful Plasmids) provided they perform the majority of Gathers. Regardless of your approach, aim to acquire seven of the Plasmid Slots before leaving Fontaine Futuristics, as extra ADAM is in short supply beyond that point. The final Plasmid Slot is gifted to you during your time in Persephone.
	Fully Upgraded a Plasmid	10	Bronze	Fully upgraded one Plasmid to the Level 3 version. The majority of the eleven Plasmid types come in three versions. The basic form is either found as part of the story progression (perhaps as a gift from Eleanor) or purchased for roughly 60 ADAM at a Gatherer’s Garden. Level 1 Plasmids can’t be charged, and are of limited effectiveness. Players can begin to purchase Level 2 Plasmids starting in Siren Alley for around 100 ADAM depending on the Plasmid. These Level 2 Plasmids can be charged for greater effect. Level 3 Plasmids typically cost roughly 120 ADAM, but are extremely powerful and feature special capabilities that the lower level Plasmids do not have. If you only upgrade one Plasmid to level 3, make sure to choose “Hypnotize”—being able to hypnotize Big Daddies, Brutes, and Alpha Series Big Daddies makes the end-game experience significantly easier.
	All Plasmids	20	Silver	Found or purchased all 11 basic Plasmid types. Each of these Plasmids is either acquired as a gift from Eleanor, left inside a red wagon in the path of your travels, or found and purchased at a Gatherer’s Garden. Acquire at least one version of each of the 11 types (no need to purchase Level 2 or Level 3) to unlock this bonus. The following table details the first appearance of each Plasmid. Note that none of these Plasmids are obtained as a thank you gift from the Little Sisters, so you needn’t rescue any to get all 11.