Approach the glass partition to begin the long-awaited meeting with Andrew Ryan. He’ll soon unlock the door to the left and come to talk up close. Listen to what he says and sit back and watch the events unfold.
With the meeting over, and the Override Key safely in your grasp, head into the main portion of Ryan’s office and take the fifty dollars from his desk. Cross the room to the southern end and use the key to stop the self-destruction of Rapture. Atlas comes on the radio to let you know how proud he is of you once the self-destruction has been stopped.
Objective 2: Escape!Ryan is dead… but Atlas/Fontaine has betrayed you! Find a way out of there, and fast! Maybe the Little Sisters can help you… 
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Run back to the main office area and follow the Little Sister crouched down in the center of the room. Security Bots and Turrets appear from beneath the globes Ryan had positioned around his office, but just ignore them. Follow the Little Sister past Ryan’s body to the Control Room area and into the maintenance shaft where the other Little Sister awaits. Turn to the right and crawl into the darkness…