The Little Sister you see in the Grand Foyer is under the watchful eye of her Big Sister—and Big Sister doesn’t want you anywhere near her! It doesn’t matter what you do though; it’s too late. You should have never come!
This fight is not yours to win. The Big Sister is far too powerful to fall victim to a Big Daddy as poorly equipped as you. Not to mention that you’re still groggy from a decade of sleep! Fortunately, the Big Sister only wants to give you a good scare. Practice tracking her speedy leaps and cartwheels, and zap her with Electro Bolt when she’s in view. Rush forward to hit her with the Drill if you’re close, otherwise fire at her with the Rivet Gun. Keep the statue between you and her at all times. She’ll occasionally pounce onto you for a melee attack. Try to time a swing of your weapon to knock her away as she gets close, but be ready to use a First Aid Kit!
Her most common attack is launching fiery projectiles, but she’ll also swing her weapon for a melee attack, and even pounce on you! Once you’ve managed to reduce her health meter by a third, the Big Sister flees through the boarded up exit. Take a deep breath once she’s gone and have a look around the room. There is ample opportunity to restock your supplies.