Little Sister Encounter
Big Daddy: Rosie
Lure the two Leadhead Splicers roaming around the Upper Wharf towards you and hit them each with Enrage. This gets them to go after the Big Daddy across the room. The Leadhead Splicers should buy you enough time to use the Grenade Launcher to lay down some Proximity Mines in the middle of the room. Once they’ve been deployed, switch to Frag Grenades and open fire. Rosie is going to attack with its Rivet Gun, so you must stay on the move. Circle-strafe around the crates and large wooden spool in the center of the room to stay out of its reach and continuously hit it with Electro Bolt and Shotgun blasts.
There’s an EVE Hypo on the floor near the crates and a First Aid Kit on the table, should you need it. Although you may be tempted to sprint to the north end of the area to get some separation from your foe, don’t do it! There’s an RPG Turret tucked away up that way and, if it’s activated, it may prove too much to deal with while simultaneously trying to fight the Big Daddy.
Continue north towards the gate and use the Wrench to smash the chain and lock holding it shut. There’s a Security Camera up the stairs on the left, so switch to Armor-Piercing ammo and very carefully step out towards the stairs to destroy the camera before it signals the alarm. Immediately access the Bot Shutdown Panel to the right of the stairs if the alarm sounds and use it to disable the Security Bots that appear. Use Telekinesis to get the Frag Grenades off the top of the wall and head up the stairs.
Climb the stairs with the Pistol drawn and fire two quick Armor-Piercing shots at the second Security Camera on the left. Hop over the crates to find plenty of Frag Grenades on the ground under the pipes and continue on to the Wharfmaster’s Office.