Objective 1: Drain Adam from Fontaine!Fontaine has infused himself with a massive dose of Adam. Your only hope of killing him is to drain the Adam out of him. When he is in the Adam inducer device you can drain his Adam. He will only return to the inducer when physically weakened. 
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Fontaine is strapped to the Adam inducer in the center of his lair and is currently not a threat. Have a quick look around his lair to note the location of the Health Station, Bot Shutdown Terminal, and Gene Bank. Also, there are a couple of storage crates that you can pilfer if in need of some last minute money for the Bot Shutdown station.
Fontaine
All of that Adam the Little Sisters have been collecting had to go somewhere. That somewhere is Fontaine. The power-hungry weasel of Rapture has built a complex Adam inducer that continuously pumps an ocean’s worth of the precious gene-altering nectar through his system. Sure, Fontaine derides the lowlife Splicers as being hooked on Adam, but the truth is that he is as reliant on Adam as anyone in Rapture. Take his Adam and you take his strength.
Boss Attacks
Fireballs
Fontaine has an advanced form of the Incinerate plasmid the likes Jack has never seen. They are very potent, travel quickly, and have quite a long burn time.
Ice Blast
This attack is similar to Jack’s Winter Blast plasmid, only a stronger version. Watch for Fontaine to unleash an icicle-laden stream that shoots across the floor in Jack’s direction. If you are hit, you will be frozen solid for a time while Fontaine continues to attack.
Plasma Shot
Rather than waste his time with a minor plasmid like Electro Bolt, Fontaine has the power to fire balls of electrified plasma that are capable of inflicting mass damage and stunning you for several seconds.
Battle Plan
Before you climb the ramp to Fontaine’s body and use the Adam Harvester the Little Sister gave you, make sure you have the SportBoost 2 tonic installed, since the extra agility will come in handy. Equip the Winter Blast 3 plasmid and approach Fontaine. Follow the on-screen prompt to drain him of the first of four bottles of Adam. Now get ready for battle.
Fontaine leaps from the machine and launch his fireball attack at you as you scramble back to your feet. Immediately strafe to the side and hit him with Winter Blast 3. Don’t worry about firing your conventional weapons at him while he’s frozen, since you aren’t going to break the ice before he thaws. Instead, grab the Grenade Launcher and wait for him to thaw—the ice should keep him stationary and give you a clean shot. Hit him as soon as he thaws and quickly resume strafing. Fontaine zips across the arena at tremendous speeds in attempt to scorch you. He’ll also continue to throw fireballs. Continue strafing in circles to avoid him and use the Winter Blast 3 plasmid to freeze him in place, then ready up another Heat-Seeking RPG or Incendiary Bolt and hit him with it as soon as he thaws.
Fontaine returns to the Adam inducer once his health has been fully depleted. This allows him to replenish his lost health, but it also gives you time to do the same. Switch to the Incinerate 3 plasmid, reload the Grenade Launcher with Heat-Seeking RPGs, and head up the ramp to drain him of his second bottle of Adam.
The second phase of the battle is similar to the first, only Fontaine now relies on an ice-based attack. Use Incinerate to counter this frosty attack and stay on the move to avoid the streams of ice heading your way. To make matters worse, Fontaine summons a pair of Security Bots to aid him in this stage of the battle. Light him up with the Incinerate 3 plasmid and run over to the Bot Shutdown Terminal and spend the 20 dollars it costs to disable the Security Bots. Continue to dodge Fontaine’s ice attacks and ready a Heat-Seeking RPG. He’ll likely go streaking past the Bot Security Terminal towards a pair of fuel cylinders—look to hit him with a Heat-Seeking RPG while he’s next to these cylinders to amplify the damage.
Quickly hack the disabled Security Bot while Fontaine is back in his Adam inducer apparatus, but don’t take too long because he will exit the chair on his own if you delay. Run up the ramp and take the third bottle of Adam while you can.
The third and final phase of the battle is the most intense. Fontaine not only switches to a lightning and plasma attack, but he also summons several Splicers to surround you—the Security Bot comes in handy now more than ever! Continue to use the Incinerate plasmid and any Heat-Seeking RPGs you have left. If you run out, switch to the Machine Gun and load it up with Antipersonnel Auto Rounds. Stay on the move, ignore the Splicers, and make sure the Fontaine is constantly on fire. That way, even when you’re fleeing his attacks he’ll be taking some damage. Dodge his dash attacks and unload on him after he comes to a halt.
Fontaine returns to the Adam inducer in attempt to refill his health once again. Rush to the machine and drain him of the fourth and final bottle of Adam before he can return to battle.
