The second Little Sister you seek is in the J. Fischer Gallery, but that’s not all that’s here. Enter the storage area on the south side of the room to find an Audio Diary, plenty of munitions, and the Drill Specialist tonic. Of course, you should probably wait to collect these goodies until after you deal with the Elite Bouncer in the middle of the room.
Big Daddy: Elite Bouncer
Enter the J. Fischer Gallery and immediately fire an Auto-Hack Dart at the Security Camera in the southeast corner of the room. Resist the temptation to befriend the Houdini Splicer in the room and, instead, kill it with the Speargun—the Hypnotize 2 effects likely wear off before you can sufficiently prepare for the fight with the Elite Bouncer. Just be sure to not hit the Big Daddy with an errant attack while you take out the Houdini Splicer.
Stay on the north side of the room and place Proximity Mines near the stairs leading down to the Elite Bouncer. String up some Trap Spears across the room and sprinkle a few Trap Rivets in the area as well. Once you’re ready to start the fight, begin filming, then fire a Rocket Spear or Frag Grenade at the target. He only has melee attacks at his disposal and must get close, so you can lure him around the room right into the traps you carefully placed. Smash the Health Station in the middle of the room if you need a First Aid Kit. Lastly, remember that you can use your very own Drill Dash attack to quickly put some distance between you and the Big Daddy!
Little Sister Encounter
Gather #1: Inside the J. Fischer Gallery
Search the back rooms of the J. Fischer Gallery for EVE Hypos and ammo, then on your way back to the Gather corpse, string up a series of Trap Spears leading down the steps to the main gallery. Place a number of Trap Rivets at the base of the stairs at the front (north) end of the room and deploy a Mini-Turret beside the Gather corpse. Look for an unexploded gas cylinder to fling at the Splicers as they come out of the doorway nearest the Gather corpse. Set the Little Sister down and stand near the Security Camera in the corner to try to attract the Leadhead Splicers towards the camera. You won’t have to deal with any Houdini Splicers during the Gather, but one or two Spider Splicers usually make their way into the room. Befriend the first one you can, then continue to befriend other Splicers as your “friends” get injured. Though tempting, don’t use Proximity Mines to protect the Little Sister, since it’s not really necessary and a waste of valuable ammunition.
Gather #2: Inside The Imago Fine Arts Gallery
There are multiple corpses from which this Gather can be performed, but it’s easiest to return to Imago Fine Arts and perform the Gather there. The numerous hacked Security Cameras and Turrets make this location more secure than you can ever hope. Reinforce the existing defenses with a couple of Trap Spears near the doorway leading to the Gather Corpse and place a few Trap Rivets on the floor in front of the door beside the corpse. Set the Little Sister down and deploy a Mini-Turret nearby, then stand in the back corner and watch for enemies to approach. The hacked Security Cameras and Turrets dispatch nearly all of the Splicers in the main area, but you’ll have to deal with those who emerge from the door to the right. You may even see a Houdini Splicer or two materialize in this area, so be on guard!
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Master Gatherer