Put your new Incinerate! ability to use by melting the iced-over exhibit to the left of the door leading back to the main area. Melt the ice behind the counter to stock up on Trap Rivets and Heavy Rivets—these can come in handy shortly—then approach the Gatherer’s Garden machine. Those who decided to harvest the Little Sister have an additional 80 ADAM to spend. It’s best to spend it on Armored Shell and an additional Gene Tonic Slot.
Kill the Big Sister
Big Sister doesn’t care whether you rescued or harvested the Little Sister—you were not her Big Daddy and you should have never have laid hands on that poor little one. The Big Sister uses her Telekinetic Plasmid to pull you through the door leading back into Rapture Museum, so you had better be ready for a fight! Have the Rivet Gun or Machine Gun on hand and immediately target the fuel drum near the bench where she is standing (this is the one mentioned earlier). You only have a moment to detonate the fuel drum before she leaps away, so make your shot count!
The Big Sister isn’t particularly vulnerable to Electro Bolt so hit her instead with Incinerate! Open fire on her head with Heavy Rivets and try to keep as far from her as possible to avoid her powerful melee slashes. Big Sister sprints and cartwheels around the area—and can even crawl along the walls if she wants to—so do your best to track her movements and stay out of the way. Avoid the back hallway where she can pin you into the corner, and consider leaping down to the lower level to play the angles against her. Switch to the Drill if she dashes in close and hold the Fire button to drill into her.
Her speed and melee attacks are your primary threat, but she’ll also attack with her own Plasmids. Dodge her fireballs and hold your fire when she’s using Telekinesis. She’ll pull a number of rocks and other objects to her and hold them up as a shield before hurling them at you. Dodge the objects, then retaliate with more fireballs of your own and Heavy Rivets. Don’t be stingy with your First Aid Kits—use one whenever your health drops below the halfway mark.
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With the Big Sister defeated, all you have to do is head back to the train station and melt the ice with the Incinerate! Plasmid. Take a moment and inspect the in-game maps to make sure that there aren’t any areas you’ve overlooked. Cycle through the map levels and look for areas colored brown on any individual level—those are areas you haven’t been to yet. There’s no place in Ryan Amusements that you can’t access.
Make your way back to the train station and melt the ice as instructed. Sinclair then tells you to head into the security booth and throw the switch to put the train back online. He’ll exit the locked room to the south and board the train, leaving you to fight your way through a half-dozen angry Splicers. Ready the Machine Gun, switch to Anti-Personnel Rounds, and have at it! Locate the Audio Diary in the room where Sinclair was, then board the train and get out of there!
Sinclair’s Solution