Kill Two Big Sisters
In theory, this should be the most difficult battle of the game up to this point—after all, you’re facing two Big Sisters at once—but it needn’t be. Position the fuel drums and gas cylinders in the center of the room in front of the Quarantine Chamber, and place several Trap Rivets and Proximity Mines around them. Set up a decoy in the middle of this monster-sized trap and use the Gene Bank to splice up Natural Camouflage to make sure the Big Sisters don’t see you first.
Have your Launcher ready and loaded up with Heat-Seeking Rockets and have Incinerate! 3 charged and set to throw in your left hand. A couple of Security Bots can help further distract the Big Sisters once the initial blast is finished. Keep your distance and strafe back and forth while hurling fireballs and rockets at the Big Sisters. They’ll make quick work of your Security Bots, but don’t bother summoning any extras unless you run out of Launcher ammo or need to buy time while you scour the area for healing supplies. Remember that you cannot befriend a Big Sister, so don’t even try. Just keep hitting them with Incinerate! 3, Heat-Seeking Rockets, and Armor-Piercing Rounds if you run out of the former. Also, it is important to note that this is your last chance to research Big Sisters.
By the time you’re done with the Big Sisters, the Quarantine Chamber is ready for you to enter. Approach the door to begin the decontamination process and…
Escape the Holding RoomWhen Lamb suffocated Eleanor, your mutual bond broke. Your body is now shutting down, and you may not have long to live. Lamb has taken advantage of this to secure you in one of Persephone Penal’s holding rooms. Eleanor, weak as she is, is the only one who can help you now. She has used her power over the Little Sisters to transfer control of one to you. Use the Little Sister’s ability to crawl through Rapture’s vents to escape the holding room. 
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