Objective 1: Get a Second Dose of Lot 192You took the compound, but it had side effects. Tenenbaum believes a second dose of Lot 192 will fully restore your splices. More of the drug can probably be found in Suchong’s lab at Artemis Suites, near Apollo Square. 
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Step out into the streets and start up the road past the Circus of Values machine towards the toppled streetcar ahead. Apollo Square is a place where a lot of innocent people have been taken and unmercifully slaughtered. The hundreds of missing person photos is a grim reminder of the force you are going up against.
Little Sister Encounter
Big Daddy: Elite Rosie
The first Little Sister is just around the bend in the road, beyond the upturned streetcar. Stand back out of sight and take your research photos while the Splicers in the street attack the Elite Rosie. Remember when preparing to battle the Elite Rosie that you don’t have control over your plasmids. You might have Telekinesis active at the moment or, perhaps you’ll have Incinerate 3. It’s a crapshoot really, so it’s best not to count on plasmids at this point at all.
Deploy several Proximity Mines while the Elite Rosie is fighting the others and fire off a Heat-Seeking RPG. There’s no guarantee that the Elite Rosie will charge you after the grenade hits home, since the fight with the Splicers may be too distracting. If so, this is your lucky day. Stand back and continue to use the Grenade Launcher and Incendiary Bolts to finish the job.
Continue up the road towards the square proper and draw the Crossbow. Use the Steel-Tip Bolt to snipe the Splicer on the gallows beneath the hanging corpses—a headshot will kill the Nitro Splicer with a single bolt. Explore the area to the right where the numerous vending machines are located. Once again, you won’t be able to access the Gatherer’s Garden because of the current Lot 192 side-effects, but the U-Invent and other machines make this area well worth visiting anyway.
From the area with the vending machines, head straight across the square to continue east towards Artemis Suites. Round the corner slowly and use the Crossbow to eliminate the Turret on the median near the trolley tracks. Wait for the Nitro Splicer to stroll into view and snipe him as well. Hop onto the median and lean out around the left-hand side of the ticket booth at the end to hack the Security Camera mounted there. The Splicers up ahead will be spotted by the Security Camera and eliminated by the Security Bots that are summoned—and all you have to do is take photos of it!
