The following table lists the 12 Runes, along with upgrade information. The Rune Trials are also covered in this chapter in the order that they appear in the game.
| Rune | Description | Upgrade Requirement | Upgrade |
|---|---|---|---|
| Vacuum | Increases the range that you can absorb dropped items. | Absorb 300 dropped items. | Further increases range for absorbing dropped items. |
| Dazed and Confused | Increases how long demons remain in a stagger state. | Perform 25 Death from Above Glory Kills. | Demon staggers last even longer. |
| Ammo Boost | Increases the value of ammo received from demons and items. | Pick up 500 Ammo Items. | BFG ammo has a chance to drop from demons. |
| Equipment Power | Increases effectiveness of Equipment items. | Use 30 Equipment Items. | Further increases effectiveness of Equipment items. |
| Seek and Destroy | Launch into a Glory Kill from much further away. | Glory Kill 75 demons. | Increases the distance that Seek and Destroy can be initiated. |
| Savagery | Perform Glory Kills faster. | Perform 25 unique Glory Kills while Savagery is equipped. | Further increases the speed of Glory Kills. |
| In-Flight Mobility | Provides a significant increase in control over in-air movement after a double jump. | Kill 30 demons while in mid-air. | Applies air control to a single jump. |
| Armored Offensive | Glory Killing demons drops armor. | Earn 2500 points of Armor. | More armor drops per Glory Kill. |
| Blood Fueled | Move faster for a short time after performing a Glory Kill. | Kill 50 demons during the speed boost. | Extends how long you can move faster after a Glory Kill. |
| Intimacy is Best | Demons become more Glory Kill friendly due to a high damage resistance when staggered. | Stagger 100 demons. | Demons stagger off of less damage. |
| Rich Get Richer | Firing your standard weapons will not cost ammo when you have 100 Armor or more. | Fill your Armor value to max 12 times. | Activate Rich Get Richer at 75 Armor. |
| Saving Throw | Get one chance to survive a death blow and recover health. This resets on death. | Kill 10 demons while Saving Throw is active. | Get an additional Saving Throw per life. |