Desmond breaks out of Abstergo, and both he and Lucy escape. They meet with others who are fighting back against the company. Rebecca Crane is in the resistance and works on Animus technology, and Shaun Hastings is the group’s historian and scholar. They, also, have a version of the Animus and connect Desmond to it. He takes on the memories of Ezio Auditore de Firenze, of Florence, Italy. And the adventure begins anew.
Ezio sees his father and brothers killed by a vicious official. This sends the rest of Ezio’s family into hiding while Ezio trains in the arts of killing. He swears revenge against this corrupt man.
Ezio’s uncle Mario and Leonardo da Vinci himself assist Ezio as he investigates and wipes out the Templars. He hears about an artifact called the Piece of Eden, which is in the form of an apple. It’s being held by Rodrigo Borgia, someone who is destined to become Pope.
A decade passes, and Ezio hears that Borgia still has the apple and carries a second Piece of Eden as well—a staff that he keeps with him.
Ezio locates Borgia and uses the Pieces of Eden to find a secret chamber. There he meets Minerva, who somehow can let Ezio and Desmond speak to each other! Minerva warns of destruction to come, harkening back to the warning of the first Assassin’s Creed. We learn that Desmond is the key to avoiding this apocalypse.
There isn’t long to process this information before Abstergo discovers the resistance hideout. Everyone is forced to flee, and that is where this story ends.