Thankfully, there is nothing tricky about shooting your weapon. However, there are two different modes of firing that can have a significant impact in combat.
All weapons are capable of firing single shots, but many weapons can fire in burst mode, too.
It might seem like you should always use burst mode to send more bullets at your target, but there are some disadvantages.
The most obvious downside to burst mode is that is uses a lot of ammo, as indicated by the burst rating of the weapon. If you intend on using burst mode, you better make sure you have enough rounds to carry you through the entire area.
The other unobvious downside to using burst mode is that the first shot is not very accurate. Thus, if you are taking on a single foe, burst mode is overkill and the increased precision of a single shot would be a better choice.
As enemies increase in level, armament, and weapons burst mode will become a necessary cost of war. As the saying goes, "fight fire with fire." So don’t respond to an assault rifle attack with a single shot unless you know it will take the enemy down.