Every Safe House has a Save Terminal. We highly recommend that you use these terminals regularly to save your game, especially after you win a tough fight, spend time upgrading weapons and skills, or advance a level or more in the Shooting Range. You don’t want to lose all that work to an untimely death. The game does keep rotating a set of Autosaves, but don’t rely on those to lock in hard or time-consuming progress. Again: Use those Save Terminals!