Runes
Go into the dining hall, on the left side of the institute. Defeat the Guards that are eating there, and look on the wall by the tables. A Rune is hung up.
From the fourth floor, go outside and stop. Look up, and Blink/Far Reach up to the rooftop. Search around for a window back into the building from up there. A Rune is just inside that window.
The Recuperation Room’s entrance is on the third floor. Unlock it once you have the Key and go inside. Destroy the first Bloodfly nest ahead, and look in the debris for a Rune.
Break the elevator cables, and Blink/Far Reach from the first floor into the elevator shaft. Hop down into the basement and search it for a Rune on the left wall.
Go out onto fourth floor walkway and follow your Heart to find an Outsider Shrine. It’s inside one of the small buildings up there.
Bonecharms
Start the mission but turn around and look for a pipe underneath the starting walkway. Blink/Far Reach down to that and search underneath the platform for a Bonecharm.
Go into the institute by the main entrance. Use your Heart to find a Bonecharm that is very close, almost on the floor.
As you’re going through the Recuperation Room on floor three, look for something that’s like an iron lung. Open these human-sized containers when you see them. One lets you crawl through into a damaged room. A Bonecharm is in there.
A Black Bonecharm is on top of the highest roof. Go to the fourth floor and Blink/Far Reach onto the middle roof above. From there, get onto a smokestack, and then onto the highest possible rooftop. A bird’s nest has the Black Bonecharm.
Dr. Hypatia is in the second floor, but it reached by going through the Recuperation Room on the third floor (it has stairs leading down at the far end). A Corrupt Bonecharm is in a small lab, near Dr. Hypatia’s work area.
Paintings
There is a Wall of Light on the first floor. Look right next to it for a Painting.
Break the elevator cables, and Blink/Far Reach from the first floor into the elevator shaft. Hop down into the basement and search it for a Painting on the left wall.
Find Dr. Hypatia’s area. Search to her right for a small lab that has a Blueprint. On the wall behind that is a Painting.
Blueprints
Go to the second floor by Blinking/Far Reaching up and right from the entrance hallway. Search the right side of the building for a Document with a safe combination. Then, look for that safe not far away from where you find the code. Open the safe and get a Blueprint for Combat Sleep Dart Formula.
Mercury Vapor Distillation’s Blueprint is inside Hamilton’s quarters. They’re directly in front of you when you enter the room.
Find Dr. Hypatia and look for a Blueprint right next to her. You learn about Dispersed Incendiary Release.
A backup Blueprint for Fire Hardening treatment is inside a small office, on the third floor. It’s close to the elevator.
