Harpies
There’s an area to the northeast of Loc Muinne where you are attacked by harpies nearly every time you pass through. You are likely to encounter them for the first time when you go to do this chapter’s Poker Face side quest. In terms of difficulty the encounter is trivial, but it can be really useful if you end up needing to grind orens in this chapter. You can just kill harpies until you have as many monster guts as you can carry, then go sell them all off. Since harpy feathers sell for so much, you can quickly rack up spare cash this way at relatively little risk to yourself.
Nilfgaardian Bounty Hunters
The first time you venture down a particular path northeast of the town square, you trigger an encounter with Nilfgaardian soldiers who want to collect the bounty on Geralt’s head. Defeating them is more challenging than beating the prior groups of bounty hunters you’ve faced, but overall should be a fairly manageable task. The main difficulty you face in this fight is the combat mage, so depending on your build you may want to make preparations before triggering the battle. The usual tricks for fighting mages work against this one, as do the usual tricks for fighting groups of armed humans.
Royal Guards
Some areas of Loc Muinne are patrolled by guards attached to the militaries of the various visiting kings. For the most part, these guards hate you and attack you if you pass by too closely. Whether your sword is unsheathed or not makes no difference; the guards tend to be hostile on sight. The thickest pack of guards you can wade into is the one in the Temerian camp, which you should only visit if you choose to resolve the main quest For a Higher Cause by getting arrested. Otherwise, entering that area is certain death since the guards infinitely respawn.
Otherwise, the main groups of guards you pass by are the guards from the Redanian camp in the town square and guards by the entrance to the Nilfgaardian camp a little north of that. Note that if you’ve already completed Where Is Triss Merigold?, the Nilfgaardian guards won’t be there. Otherwise, be cautious while heading toward the area where the harpies spawn or areas beyond. You pass rather closely to the Nilfgaardian camp. You also pass by the Redanian guard whenever dealing with the main town square merchants.
Street Preacher
Just across the street from the Eternal Fire is a street preacher who springs to life and begins haranguing the crowd whenever you pass by. This guy has nothing to do with any quests or getting loot, but you should pause and listen to his full rants once. He has two rants, both of which are too long and rambling to hear completely while you’re just running around. They’re pretty hilarious if you hear them in full, though, so pause if you happen to hear him saying something new while you run by.