Mutagens work like runes and armor enhancements, only they directly enhance Geralt’s stats. Mutagens are equipped to mutagen slots that are opened up when talents are invested in certain skills, usually the skills in the upper half of a given skill tree. Like other enhancements, mutagens cannot be removed once they’ve been equipped into a slot.
Mutagens cannot be purchased. For the most part, they are obtained as random drops when defeating monsters or crafting alchemy items (if you take the right skill from the alchemist skill tree). It’s worth noting that if you slot a mutagen to a skill and then re-spec your skills with the Operator or Lady Adrianna, you retain the mutagen’s effect even if you do not repurchase the skill.
Since you cannot remove a mutagen once you’ve slotted it, it’s best to slot only the strongest mutagens. Lesser mutagens are ideally sold off or held onto until the very end of the game, to slot in case you somehow never find anything better. Generally, any greater mutagens, madness mutagens, range mutagens, and concentration mutagens are worth slotting (depending on your build).
| Mutagen | Type | Substance | Effect 1 | Effect 2 | Effect 3 | Effect 4 | Effect 5 | Effect 6 | Orens | Weight |
|---|---|---|---|---|---|---|---|---|---|---|
| Concentration | Epic | Caelum | Damage bonus on signs +1 | 44 | 0.1 | |||||
| Critical Effects | Magical | Rebis | Knockdown +2% | Stun +2% | Freeze +2% | Incineration +2% | Poison +2% | Bleeding +2% | 13 | 0.1 |
| Enhancement | Epic | Vitriol | Adrenaline generation on hitting foe +3% | 16 | 0.1 | |||||
| Greater Critical Effects | Rare | Rebis | Knockdown +3% | Stun +3% | Freeze +3% | Incineration +3% | Poison +3% | Bleeding +3% | 33 | 0.1 |
| Greater Enhancement | Epic | Vitriol | Adrenaline generation on hitting foe +5% | 39 | 0.1 | |||||
| Greater Power | Magical | Quebrith | Damage +(1-3) | 35 | 0.1 | |||||
| Greater Strength | Rare | Vermilion | Armor +2 | Vitality regeneration +1 | 42 | 0.1 | ||||
| Greater Vitality | Rare | Hydragenum | Vitality +10 | 45 | 0.1 | |||||
| Lesser Critical Effects | Magical | Rebis | Knockdown +1% | Stun +1% | Freeze +1% | Incineration +1% | Poison +1% | Bleeding +1% | 7 | 0.1 |
| Lesser Enhancement | Epic | Vitriol | Adrenaline generation on hitting foe +1% | 9 | 0.1 | |||||
| Lesser Power | Magical | Quebrith | Damage +1 | 8 | 0.1 | |||||
| Lesser Range | Rare | Aether | Aard sign range +2% | Igni sign range +2% | 7 | 0.1 | ||||
| Lesser Strength | Magical | Vermilion | Armor +1 | 11 | 0.1 | |||||
| Lesser Vitality | Magical | Hydragenum | Vitality +2 | 13 | 0.1 | |||||
| Madness | Epic | Caelum | Armor +2 | Damage bonus on signs +1 | Vitality +5 | 63 | 0.1 | |||
| Power | Magical | Quebrith | Damage +(1-2) | 14 | 0.1 | |||||
| Range | Rare | Aether | Aard sign range +5% | Igni sign range +5% | 14 | 0.1 | ||||
| Strength | Magical | Vermilion | Armor +2 | 18 | 0.1 | |||||
| Vitality | Magical | Hydragenum | Vitality +5 | 7 | 0.1 |