The Cast of The Callisto Protocol – Listed

All voice actors in the Callisto Protocol listed

The Callisto Protocol, 2022’s most highly anticipated horror game, is merely one week away. The new sci-fi horror debut from developer Striking Distance Studios and published by Krafton will release on December 2, 2022 to the jubilation of horror gamers who have long awaited a spiritual successor to the Dead Space franchise.

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To help the title live up to its lofty expectations, The Callisto Protocol’s developers have enlisted some recognizable names from Hollywood and even veteran videogame talent to comprise its notable cast. Let’s meet the actors and actresses whose performances will be witnessed in The Callisto Protocol, arriving on December 2, 2022 for PC, PlayStation 4, PlayStation 5, Xbox One, and Xbox Series X|S.

Josh Duhamel as Jacob Lee in The Callisto Protocol

The earliest confirmed cast member of The Callisto Protocol is Hollywood action hero Josh Duhamel, who will reportedly serve as the game’s protagonist, Jacob Lee, providing the voice and motion capture performance. Duhamel is known for his many appearances in Michael Bay’s sci-fi action Transformers film franchise, and has previously lent his acting talents to Call of Duty: WWII in 2017. For more information on Josh Duhamel and his filmography, follow the related link below.

Related: Who Voices the Protagonist in The Callisto Protocol? – Answered

Karen Fukuhara as Dani Nakamura in The Callisto Protocol

Karen Fukuhara is making her videogame acting debut in The Callisto Protocol as Dani Nakamura. Her first prominent acting role was in the 2016 DC comics film Suicide Squad, and the 30 year old actress is most well-known as being a cast member on Amazon’s popular superhero television series, The Boys. Most recently, she portrayed “Kayda Izumi, the train concession girl” in the 2022 Brad Pitt-led action comedy, Bullet Train.

Gwendoline Christie as Percy in The Callisto Protocol

While it is unclear if Gwendoline Christie will appear in The Callisto Protocol, she is currently starring in The Callisto Protocol: Helix Station, a six-part prequel podcast to the game. Christie’s most recognizable acting performance was in the iconic HBO television series Game of Thrones, as Brienne of Tarth, earning the actress an Emmy nomination. She has previously appeared in the science fiction blockbuster Star Wars film series (and videogames) as Captain Phasma as well. For more information on The Callisto Protocol’s Helix Station podcast, follow the related link below.

Related: Where to Listen to The Callisto Protocol Prequel Podcast Helix Station

Michael Ironside as Kane in The Callisto Protocol

Michael Ironside is a veteran science fiction actor known for a variety of blockbuster titles and cult classics in his 45 year long acting career. His most notable film performances include Scanners, Top Gun, Total Recall, and Starship Troopers, which are but a mere sampling of Ironside’s filmography. He also has an impressive catalog of videogame performances, such as eight appearances in the Tom Clancy games as NSA Agent Sam Fisher between 2002 and 2020. Most recently, Ironside performed alongside Gwendoline Christie in The Callisto Protocol: Helix Station podcast.

Sam Witwer as Captain Leon Ferris in The Callisto Protocol

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Last, but certainly not least is veteran videogame actor, Sam Witwer, who has acted in both science fiction and horror media. In terms of sci-fi, Witwer’s breakout videogame role was as Starkiller in Star Wars: The Force Unleashed series, as well as frequently voicing Emperor Palpatine and Darth Maul in Star Wars television and gaming content. In the realm of horror, Witwer portrayed Deacon St. John in the 2019 PlayStation 4 exclusive zombie action horror title, Days Gone, and appeared in the cult classic film, The Mist. He is rumored to be the antagonist of The Callisto Protocol.

For more news, reviews, features, and guides on The Callisto Protocol and the videogame industry, Prima Games is your go-to source.


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Grant Testa
Grant Testa is a writer at Prima Games, who specializes in achievement hunting and horror gaming. He is also an avid comic book reader/collector, fantasy footballer, and rock music fanatic. Thousands who have been defeated by Grant in online multiplayer games have cried to themselves, wondering, "How did he get so good?! Why can't I be a gaming demigod like him?" They would probably be surprised to learn that Grant actually inherited his elite gaming skills from his mom, Joann Hansen, one of the speediest stenographers/typists in the nation, (and probably the world). Fun fact: he is also the son of the world’s first “let’s player” and comedy legend, Tim Testa.